Atypical Behavior Research Articles

Distance-based novelty detection model for identifying individuals at risk of developing Alzheimer's disease

IntroductionNovelty detection (ND, also known as one-class classification) is a machine learning technique used to identify patterns that are typical of the majority class and can discriminate deviations as novelties. In the context of Alzheimer's disease (AD), ND could be employed to detect abnormal or atypical behavior that may indicate early signs of cognitive decline or the presence of the disease. To date, few research studies have used ND to discriminate the risk of developing AD and mild cognitive impairment (MCI) from healthy controls (HC).MethodsIn this work, two distinct cohorts with highly heterogeneous data, derived from the Australian Imaging Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing project and the Fujian Medical University Union Hospital (FMUUH) China, were employed. An innovative framework with built-in easily interpretable ND models constructed solely on HC data was introduced along with proposing a strategy of distance to boundary (DtB) to detect MCI and AD. Subsequently, a web-based graphical user interface (GUI) that incorporates the proposed framework was developed for non-technical stakeholders.ResultsOur experimental results indicate that the best overall performance of detecting AD individuals in AIBL and FMUUH datasets was obtained by using the Mixture of Gaussian-based ND algorithm applied to single modality, with an AUC of 0.8757 and 0.9443, a sensitivity of 96.79% and 89.09%, and a specificity of 89.63% and 90.92%, respectively.DiscussionThe GUI offers an interactive platform to aid stakeholders in making diagnoses of MCI and AD, enabling streamlined decision-making processes. More importantly, the proposed DtB strategy could visually and quantitatively identify individuals at risk of developing AD.

Validity of the multidimensional assessment profile of disruptive behavior in autistic toddlers

AbstractObjectiveEarly measurement of atypical disruptive behavior within autistic children is critical for later referrals to behavioral screenings, diagnoses, and services. Disruptive behavior in autistic toddlers is often measured using a categorical approach and identifies the presence or absence of behavior. In contrast, dimensional approaches evaluate behavior on a spectrum of typical to atypical by measuring the clinical salience of disruptive behavior. We sought to assess the validity of the Infant/Toddler version of the multidimensional assessment profile of disruptive behavior (MAP‐DB‐IT), a dimensional approach measurement tool, in a sample of autistic toddlers.MethodsAutistic toddlers (n = 82, Mage = 33.2 months, SD = 6.28 months) and their mothers received 8 weeks of caregiver‐mediated social communication intervention. Mothers completed the MAP‐DB‐IT and the Infant Toddler Social Emotional Assessment (ITSEA) across three timepoints: before intervention, immediately after intervention, and at 3 months post‐intervention follow‐up. The MAP‐DB‐IT provided scores for three subdomains: temper loss, noncompliance, and aggression (generically or specifically with siblings). Ratings on the MAP‐DB‐IT were compared to the ITSEA using several analytic strategies such as evaluating (a) the internal consistency of the MAP‐DB‐IT domain scores; (b) the convergent validity between the two measures; and (c) its convergent change due to intervention and if this varied by child characteristics.ResultsThe MAP‐DB‐IT demonstrated excellent internal consistency across all four subdomains. We evaluated convergent validity and found positive correlations between the (a) ITSEA externalizing and MAP‐DB‐IT aggression domain, (b) ITSEA externalizing and MAP‐DB‐IT aggression with siblings domain, and (c) ITSEA dysregulation and MAP‐DB‐IT temper loss domain.ConclusionThe MAP‐DB‐IT is a valid measurement tool for disruptive behavior in autistic toddlers. Clinicians should consider the use of the MAP‐DB‐IT for young autistic clients presenting with disruptive behavior to (a) discriminate between early developmentally appropriate tantrums from clinically salient dysregulation, and (b) refer to additional behavioral evaluations and services.

Forecasting Hourly Wildfire Risk: Enhancing Fire Danger Assessment using Numerical Weather Prediction

Abstract Wildfire agencies use Fire Danger Rating Systems (FDRS) to deploy resources and issue public safety measures. The most widely used FDRS is the Canadian Fire Weather Index (FWI) System, which uses weather inputs to estimate the potential for wildfires to start and spread. Current FWI forecasts provide a daily numerical value, representing potential fire severity at an assumed midafternoon time for peak fire activity. This assumption, based on typical diurnal weather patterns, is not always valid. To address this, we developed an hourly FWI (HFWI) system using numerical weather prediction. We validate HFWI against the traditional daily FWI (DFWI) by comparing HFWI forecasts with observation-derived DFWI values from 917 surface fire weather stations in western North America. Results indicate strong correlations between forecasted HFWI and the observation-derived DFWI. A positive mean bias in the daily maximum values of HFWI compared to the traditional DFWI suggests that HFWI can better capture severe fire weather variations regardless of when they occur. We confirm this by comparing HFWI with hourly Fire Radiative Power (FRP) satellite observations for nine wildfire case studies in Canada and the United States. We demonstrate HFWI’s ability to forecast shifts in fire danger timing, especially during intensified fire activity in the late evening and early morning hours, while allowing for multiple periods of increased fire danger per day—a contrast to the conventional DFWI. This research highlights the HFWI system’s value in improving fire danger assessments and predictions, hopefully enhancing wildfire management, especially during atypical fire behavior.

Does the CEO’s entrenchment affect the financial communication quality? Empirical evidence from France

Research Question: What is the impact of the CEO’s entrenchment on the financial communication quality in the French context? otivation: In fact, it is important to study the different characteristics of the CEO, which can facilitate the entrenchment and their effect on the quality of financial communication in the French context. Idea: The purpose of this paper is to investigate the impact of the CEO’s entrenchment on the financial communication quality examined by the discretionary accruals. Data: Our sample is made up of 335 companies listed on the CAC All Tradable index for the period from 2011 to 2020. However, we have excluded some financial companies due to their atypical behavior in financial reporting, firms with insufficient annual reports and firms with insufficient data about the CEO’s entrenchment. Therefore, the final number of firms used in this study was 151 over ten years, producing a total of 1510 firm-year observations. Tools: Our regressions will be estimated by the feasible generalized least squares (FGLS) method. Findings: Using the discretionary accruals, as a proxy for the earnings management, we obtained results from the Kothari et al. (2005) model, which indicates that there is a significant positive relationship between the CEO’s duality, ownership and the quality of financial communication, while there is no significant relationship between the CEO’s turnover and the financial communication quality. Contribution: This research is a contribution to the literature by demonstrating how the CEOs' entrenchment enables them to manipulate the accounting results to improve their financial situation.

Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour.

Imprinted genes are expressed from one parental allele as a consequence of epigenetic processes initiated in the germline. Consequently, their ability to influence phenotype depends on their parent-of-origin. Recent research suggests that the sex of the individual expressing the imprinted gene is also important. We have previously reported that genetically wildtype (WT) dams carrying and caring for pups mutant for PEG3 exhibit anxiety-like behaviours and their mutant pups show a reduction in ultrasonic vocalisation when separated from their mothers. Sex-specificity was not examined. WT female mice were mated with WT, heterozygous Peg3-/+ or homozygous Peg3-/- studs to generate all WT (control), 50:50 mixed or 100% mutant litters, respectively, followed by behavioural assessment of both dams and their pups. We reproduced our original finding that WT dams carrying and caring for 100% mutant litters exhibit postpartum anxiety-like symptoms and delayed pup retrieval. Additionally, these WT dams were found to allocate less time to pup-directed care behaviours relative to controls. Male Peg3-deficient pups demonstrated significantly reduced vocalisation with a more subtle communication deficit in females. Postweaning, male mutants exhibited deficits across a number of key social behaviours as did WT males sharing their environment with mutants. Only modest variations in social behaviour were detected in experimental females. We have experimentally demonstrated that Peg3 deficiency confined to the offspring causes anxiety in mouse mothers and atypical behaviour including deficits in communication in their male offspring. A male-specific reduction in expression PEG3 in the fetally-derived placenta has previously been associated with maternal depression in human pregnancy. Maternal mood disorders such as depression and anxiety are associated with delays in language development and neuroatypical behaviour more common in sons. Peg3 deficiency could drive the association of maternal and offspring behavioural disorders reported in humans.

Patterns of Referral and Clinical Presentation of Autism Spectrum Disorder in Children at Al Jalila Children Specialty Hospital: A Retrospective Descriptive Study

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is gradually gaining popularity. However, there is minimal scientific research exploring the clinical presentation of this highly complex disorder and the general understanding of such varying presentations by general practitioners and pediatric physicians. Objective: This study aims to explore the patterns of referral of patients with ASD to a tertiary hospital in Dubai, United Arab Emirates, and to understand better and analyze the general knowledge of referring physicians through their impression of the patient’s clinical presentation Methods: This is a retrospective descriptive study where all the data were collected electronically from past medical records and referral documents taken from Al Jalila Children's Specialty Hospital (AJCH). Patients who were referred were later assessed by the neurodevelopmental specialists using the NICE Guidelines. The data were analyzed statistically and described using different statistical tools. These results were then considered in light of the local clinician's needs for diagnostic support and the possibility of developing a national screening program for ASD. Results: Within a sample of 90 referrals, 69 (76.7%) were predominantly male, 73 (81.1%) were Emirati nationals, and the majority fell within the age group of 0 to 5 years old. Of the 90 referred patients, 53 (58.9%) were diagnosed with ASD by neurodevelopmental specialists using the NICE Guidelines. Physicians were keen on picking up features of speech and language deficits, hyperactivity, and inappropriate or atypical behavior. However, they seemed hesitant and required further assessment when interpreting and reporting features revolving around social communicative skills, interaction and rapport, and evaluating patients’ ideas and imagination. Conclusion: Physicians practicing in the United Arab Emirates (UAE) are advised to assess the full range of clinical symptoms of ASD according to their respective categories as listed in the National Institute for Health and Care Excellence (NICE) guidelines. Furthermore, the Dubai Health Authority (DHA) has published the first edition document titled “Dubai Clinical Practice Guidelines for Autism Spectrum Disorder (ASD) in Children and Adolescents,” designed to align physician recognition and practice with the government's objectives toward all individuals with ASD. Their achievement aligns with the goals of our study as it will make the clinical recognition of ASD clinically more sound and prevent misdiagnosis. Finally, the authors hope that this study aids in developing a national screening program dedicated to general practitioners and pediatric physicians in providing a structured assessment for ASD, which in return will result in early intervention by neurodevelopmental specialists for further diagnosis and management, ultimately improving the quality of life of the patients and their families.

Variation in coupling across neural and cardiac systems of regulation is linked to markers of anxiety risk in preschool.

Both cortical and parasympathetic systems are believed to regulate emotional arousal in the service of healthy development. Systemic coordination, or coupling, between putative regulatory functions begins in early childhood. Yet the degree of coupling between cortical and parasympathetic systems in young children remains unclear, particularly in relation to the development of typical or atypical emotion function. We tested whether cortical (ERN) and parasympathetic (respiratory sinus arrhythmia [RSA]) markers of regulation were coupled during cognitive challenge in preschoolers (N = 121). We found no main effect of RSA predicting ERN. We then tested children's typical and atypical emotion behavior (context-appropriate/context-inappropriate fear, anxiety symptoms, neuroendocrine reactivity) as moderators of early coupling in an effort to link patterns of coupling to adaptive emotional development. Negative coupling (i.e., smaller ERN, more RSA suppression or larger ERN, less RSA suppression) at age 3 was associated with greater atypical and less typical emotion behaviors, indicative of greater risk. Negative age 3 coupling was also visible for children who had greater Generalized Anxiety Disorder symptoms and blunted cortisol reactivity at age 5. Results suggest that negative coupling may reflect a maladaptive pattern across regulatory systems that is identifiable during the preschool years.

Gut microbiota contribute to variations in honey bee foraging intensity.

Gut microbiomes are increasingly recognized for mediating diverse biological aspects of their hosts, including complex behavioral phenotypes. Although many studies have reported that experimental disruptions to the gut microbial community result in atypical host behavior, studies that address how gut microbes contribute to adaptive behavioral trait variation are rare. Eusocial insects represent a powerful model to test this, due to their simple gut microbiota and complex division of labor characterized by colony-level variation in behavioral phenotypes. Although previous studies report correlational differences in gut microbial community associated with division of labor, here, we provide evidence that gut microbes play a causal role in defining differences in foraging behavior between European honey bees (Apis mellifera). We found that gut microbial community structure differed between hive-based nurse bees and bees that leave the hive to forage for floral resources. These differences were associated with variation in the abundance of individual microbes, including Bifidobacterium asteroides, Bombilactobacillus mellis, and Lactobacillus melliventris. Manipulations of colony demography and individual foraging experience suggested that differences in gut microbial community composition were associated with task experience. Moreover, single-microbe inoculations with B. asteroides, B. mellis, and L. melliventris caused effects on foraging intensity. These results demonstrate that gut microbes contribute to division of labor in a social insect, and support a role of gut microbes in modulating host behavioral trait variation.

Unveiling Three Interconvertible Redox States of Boraphenalene.

Neutral 1-boraphenalene displays the isoelectronic structure of the phenalenyl carbocation and is expected to behave as an attractive organoboron multi-redox system. However, the isolation of new redox states have remained elusive even though the preparation of neutral boron(III)-containing phenalene compounds have been extensively studied. Herein, we have adopted an N-heterocyclic carbene ligand stabilization approach to achieve the first isolation of the stable and ambipolar 1-boraphenalenyl radical 1•. The 1-boraphenalenyl cation 1+ and anion 1- have also been electrochemically observed and chemically isolated, representing new redox forms of boraphenalene for the study of non-Kekulé polynuclear benzenoid molecules. Experimental and theoretical investigations suggest that the interconvertible three-redox-state species undergo reversible electronic structure modifications, which primarily take place on the polycyclic framework of the molecules, exhibiting atypical behavior compared to known donor-stabilized organoboron compounds. Initial reactivity studies, aromaticity evaluations, and photophysical studies show redox-state-dependent trends. While 1+ is luminescent in both the solution and solid states, 1• exhibits boron-centered reactivity and 1- undergoes substitution chemistry on the boraphenalenyl skeleton and serves as a single-electron transfer reductant.

A qualitative enquiry into the challenging roles of caregivers caring for children with Autism Spectrum Disorders in Ghana

BackgroundAutism Spectrum Disorder (ASD) is a condition commonly characterized by challenges with social interaction, repetitive atypical behaviour, and restricted interest. It is estimated that about 1 in 160 children has ASD. Caring for children with ASD is challenging for many parents or caregivers. ObjectivesThe study aims at exploring the challenges experienced by caregivers of children with ASD. MethodsA qualitative phenomenological study was employed using an exploratory descriptive research design. A total of 10 participants were recruited in this study using a purposive sampling technique. Data were analysed using content analysis procedures. ResultCaregivers of children with ASD face social, financial, and emotional challenges, challenges in accessing health care, education and training of their children in mainstream school settings. ConclusionThe numerous challenges have implications for the quality of life of the caregivers and their children. The financial challenges and inaccessibility of specialist health services have serious implications for the continuous medical care and monitoring of children with ASD. The challenges in education and training of children with ASD has negative consequences for enrolment and retention of children with ASD in mainstream school settings.

(Invited) Solvation Control in Deep Eutectic Solvent Electrolytes for Stable Plating/Stripping of Zn in Battery Applications

Within the field of battery applications, deep eutectic solvents (DESs) have emerged as innovative electrolytes for rechargeable Zinc-ion batteries (ZIBs) . ZIBs traditionally employ neutral or weakly acidic aqueous electrolytes, which are susceptible to the standard anode drawback such as dendrite formation and passivation. DES-based electrolytes can facilitate the reversible plating and stripping of Zn, mitigating also dendrite growth . One notable benefit of DES solvents over their aqueous counterparts is that the concentration of electroactive species controls the shape evolution of electrodes during electroplating. For this reason, the coordination chemistry and metal complex formed between the Lewis acid of the metal and the Lewis base of the DES play a central role. Moreover, water can be added to the eutectic mixtures to increase the diffusion coefficient of the electroactive species and lower the electrolyte viscosity without destroying the eutectic nature if the concentration is kept under 40%.Regarding metal plating/stripping processes, DESs offer a notable advantage due to their high capacity to dissolve metal salts, oxides, and hydroxides, inhibiting the formation of insoluble oxides and hydroxides . Moreover, the unique coordination properties of Zn2+ in DESs lead to an atypical voltammetric behavior, characterized by a cathodic peak in the cathodic branch of the anodic-going scan. The mechanistic studies of Zn electrodeposition onto glassy carbon (GC) from DESs have concluded that the metal is formed by the reduction of an intermediate Zn-containing species. Finally, the reactivity of choline chloride and ethylene glycol can impact coordination in that these species can be dehydrogenated at negative potential forming RO¯, which can replace one or more chloride ligands in [ZnCl4]2− . The correlation between the chemistry of Zn2+ solutions and DESs is elucidated, and the peculiarities of Zn electrochemistry can be rationalized in terms of the DES–electrode interface structure. Although few studies on hydrated DESs have been conducted, the literature remains scant.Shi et al. conducted a study on DES composed of ZnCl2 and acetamide with different concentration of water. The authors employed various spectroscopic techniques, including FT-IR, Raman, and 17O NMR, to investigate the effect of water on the coordination geometry of Zn2+ and its consequent impact on Zn plating. Interestingly, the authors observed that the addition of small amounts of water, below the threshold for direct water-water interaction, resulted in significant alterations of the Zn2+ coordination geometry. In fact, based on the accepted view that Zn electrodeposition is a process that involves desolvation and charge-transfer steps, [ZnCl(acetamide)2(H2O)]+ was shown to undergo successive deamidation and dehydration, yielding [ZnCl(acetamide)]+ from which the metal center is finally reduced. Although [ZnCl(acetamide)3]+ is the most stable species, the energy barrier for dehydration is significantly lower than that for deamidation. Therefore, [ZnCl(acetamide)2(H2O)]+ with lower dissociation energy is the actual electroactive species . The solvation of Zn also affects the nucleation overpotential, as Zn2+ in hydrated DES exhibits faster desolvation kinetics, resulting in a lower nucleation overpotential. In addition, Zhao et al. investigated the properties of a “water-in-DES” electrolyte (~30 mol.% H2O) based on the urea/LiTFSI/Zn(TFSI)2 mixture and discovered that the preferential interaction between water and metal cations promotes interfacial charge transfer. Notwithstanding the important contribution of these papers, the mechanism of Zn electrodeposition in DES has not been conclusively assessed. To address this knowledge gap, our research aims to investigate Zn electrodeposition from two distinct, hydrated DESs: ChU and ChEG with approximately 30% H2O content. To gain control of the impact of the cathode material, we carried out our electrochemical tests by employing GC, Zn, Pt and Au electrodes. Furthermore, to evaluate the performance of these electrolytes under realistic device conditions, electrochemical cycling tests were conducted on symmetric CR2023 coin cells.In this study, we have demonstrated the beneficial effect of water addition on reducing the electrolyte viscosity, which consequently resulted in lower anodic and cathodic overpotentials and improved charge/discharge cyclability. Specifically, the electrolytes ChEG and ChU failed due to passivation and short circuits, respectively. The ChU electrolyte showed regular chronopotentiometric transients until cell failure, and this was supported by multiple cyclic voltammetry (CV) measurements, which showed reversible Zn plating/stripping in this system. Notably, our cell cycling tests were performed at higher current densities and exhibited longer lifetimes compared to previous literature reports. The unusual CV patterns observed with gold and glassy carbon (GC) electrodes, featuring cathodic peaks on both forward and backward scans, were elucidated using complementary electrochemical and in situ Raman spectroscopy measurements. Figure 1

Assessing Admiration for Women Who Do “Men’s Work”

Abstract Drawing on interviews and focus groups from Conakry, the capital city of the Republic of Guinea in West Africa, this article examines how people talk about women working in male-dominated skilled trades alongside women’s accounts of their work experiences in those sectors. We find that the idea of women doing gender atypical work, whom we call “crossovers,” evokes widespread admiration. They are unanimously described as brave and virtuous, contrasted with women who rely on money from relationships with men. However, this celebration falters in the workplace, where crossovers often experience paternalism and harassment. Building on theories of both gender beliefs and femininities, we attribute this discrepancy to the differential threats to the gender order that are posed by accommodating crossovers at work versus speaking positively about them. Working together requires men to confront actual women’s unexpected capabilities, while rhetorically celebrating crossovers may in fact reify stereotypes about most women and fail to fundamentally undermine men’s authority. Crossovers can serve as sources of inspiration for an alternative gender order, but we find that professed admiration for “exceptional” groups of women has both limitations and risks. We conclude by suggesting that the subversive potential of admiration for gender atypical behavior must be empirically examined, rather than assumed, with attention to why such women are seen as admirable as well as how this admiration is borne out in social interactions.

Assistance to families of children with Autism Spectrum Disorders: Perceptions of the multiprofessional team.

to synthesize the care provided by health professionals, at different care levels, to the families of children with Autism Spectrum Disorders. a qualitative study, based on the Family-Centered Care philosophical theoretical framework and developed with 22 professionals from three multidisciplinary teams from the Health Care Network of a municipality in the state of Mato Grosso do Sul, Brazil. The data were collected through two focus groups with each team, organized with the support of the Atlas.ti 8 Qualitative Data Analysis® software and submitted to Thematic Content Analysis. the findings show actions centered on specific situations, especially on the demands and needs arising from the child's care and atypical behavior. Influencing factors for family care, such as work overload and little professional experience, show the weakness of multiprofessional care and the invisibility of the family as a care unit. the need is highlighted to review functioning of the network for the multiprofessional care of children and their families and how such network is organized. It is recommended to offer permanent education actions that contribute to the qualification of multiprofessional teams in the care of families of children in the autism spectrum.

The model of vessel trajectory abnormal behavior detection based on graph attention prediction and reconstruction network

The identification of atypical vessel behavior is a crucial factor in ensuring the safety of maritime navigation and enhancing the effectiveness of waterway oversight. The current approach to detecting vessel abnormal behavior lacks consideration for the inter-dependency among different time series and various characteristics associated with abnormal vessel behavior. Additionally, the subjective setting of anomaly detection threshold adversely affects the real-time performance of anomaly detection, resulting in poor detection accuracy. In order to tackle these issues, this paper explores the monitoring and detection mechanism of vessel abnormal behavior based on Graph Attention Prediction and Reconstruction Network. The proposed mechanism employs a sliding window to generate fixed data input. It effectively captures the inter-dependencies among vessel behavior characteristics. Additionally, it dynamically adjusts the threshold for identifying anomalies based on variations in the marine environment, utilizing the Peak Over Threshold (POT) method. In order to achieve real-time detection of abnormal vessel behavior in multivariate, multi-dimensional time series data, it is necessary to complete the task. The results of the paper are derived from an analysis of the AIS dataset encompassing vessel movements between Dalian and Yantai. The temporal scope of the dataset spans from November 1, 2021, to December 31, 2021. The detection accuracy, detection precision and recall rate are 98.29%, 92.44%, 87.09% respectively. The results indicate that there is an enhancement in the accuracy of detecting abnormal behavior in vessels, leading to a significant reduction in the blind area of VTS (Vessel traffic services) system monitoring.

Repetition Suppression for Familiar Visual Words Through Acceleration of Early Processing.

The visual N1 (N170) component with occipito-temporal negativity and fronto-central positivity is sensitive to visual expertise for print. Slightly later, an N200 component with an increase after stimulus repetition was reported to be specific for Chinese, but found at centro-parietal electrodes against a mastoid reference. Given the unusual location, temporal proximity to the N1, and atypical repetition behavior, we aimed at clarifying the relation between the two components. We collected 128-channel EEG data from 18 native Chinese readers during a script decision experiment. Familiar Chinese one- and two-character words were presented among unfamiliar Korean control stimuli with half of the stimuli immediately repeated. Stimulus repetition led to a focal increase in the N1 onset and to a wide-spread decrease in the N1 offset, especially for familiar Chinese and also prominently near the mastoids. A TANOVA analysis corroborated robust repetition effects in the N1 offset across ERP maps with a modulation by script familiarity around 300ms. Microstate analyses revealed a shorter N1 microstate duration after repetitions, especially for Chinese. The results demonstrate that the previously reported centro-parietal N200 effects after repetitions reflect changes during the N1 offset at occipito-temporal electrodes including the mastoids. Although larger for Chinese, repetition effects could also be found for two-character Korean words, suggesting that they are not specific for Chinese. While the decrease of the N1 offset after repetition is in agreement with a repetition suppression effect, the microstate findings suggest that at least part of the facilitation is due to accelerated processing after repetition.

Development and validation of a questionnaire for assessing pathomorphoisis and pathoplasty of stereotypes in autism spectrum disorders and schizophrenia in childhood

Relevance: repetitive behaviors, limited interests, and other unusual sensory behaviors often significantly affect the lives of many people with developmental disabilities, including but not limited to autism spectrum disorder (ASD) and childhood schizophrenia (PSD). Identification of specific patterns of atypical behavior in these disorders can improve the specificity of diagnoses and monitor response to treatment. Therefore, it would be useful to have an approved questionnaire for the assessment of pathomorphosis and pathoplasty of stereotypes in ASD and schizophrenia in childhood, aimed at parents and caregivers of children in this cohort. Objective: To develop and validate a questionnaire for assessing the manifestations and dynamics of stereotypes in ASD and ADHD in childhood, aimed at parents and guardians of children in this cohort, for further use in clinical practice. Materials and Methods: in accordance with international and Russian standards, a questionnaire was developed to assess the manifestations and dynamics of stereotypes and tested on a focus group of parents (legal representatives) of children diagnosed with ASD and PSD, followed by an assessment of the results of psychodiagnostic testing - reliability, validity and sensitivity of the results obtained. developed questionnaire. Statistical analysis was performed using Statistica, version 9.0. Results: according to the results of testing with the participation of a group of parents (legal representatives) of the selected cohort, the acceptability of the questionnaire and high validity rates were confirmed. The conducted factor analysis testifies to the adequacy of the grouping of questions of the questionnaire according to the expected factors and stable construct validity. Conclusion: the results obtained indicate the reliability, validity and sensitivity of the questionnaire for assessing the manifestations and dynamics of stereotypes in ASD and SDV in childhood and the possibility of its use in epidemiological studies both for clinical practice and for scientific purposes in the field of psychiatry.

Detecting unexpected growths in health technologies expenditures: the case of MIPRES in Colombia

We developed an algorithm to explore unexpected growth in the usage and costs of health technologies. We exploit data from the expenditures on technologies funded by the Colombian government under the compulsory insurance system, where all prescriptions for technologies not included in an explicit list must be registered in a centralized information system, covering the period from 2017 to 2022. The algorithm consists of two steps: an outlier detection method based on the density of the expenditures for selecting a first set of technologies to consider (39 technologies out of 106,957), and two anomaly detection models for time series to determine which insurance companies, health providers, and regions have the most notorious increases. We have found that most medicines associated with atypical behavior and significant monetary growth could be linked to the use of recently introduced drugs in the market. These drugs have valid patents and very specific clinical indications, often involving high-cost pharmacological treatments. The most relevant case is the Burosumab, approved in 2018 to treat a rare genetic disorder affecting skeletal growth. Secondly, there is clear evidence of anomalous increasing trend evolutions in the identified enteral nutritional support supplements or Food for Special Medical Purposes. The health system did not purchase these products before July 2021, but in 2022 they represented more than 500,000 USD per month.

B - 112 Navigating your Survivorship Journey: Leveraging the Biopsychosocial Model in Conceptualization and Continued Care for Brain Tumor Survivors.

A neuropsychological assessment provides a limited snapshot of functioning based on the aperture of the lens selected. The journey of cancer survivorship is complex, requiring navigation of the social and cultural milieu (Carpentieri et al., 2003; Hoffmann-Lamplmair et al., 2023; Hörnquist et al., 2015; Otth et al., 2021). A biopsychosocial model provides a holistic approach to understanding survivorship (Walsh et al., 2016). The case conceptualization of a 17-year-old non-Hispanic Asian male posterior fossa tumor survivor, 13years post-treatment, will be discussed. Longitudinal neuropsychological assessment data [2011-2023] were compared to identify neurocognitive late effects associated with chemoradiotherapy. Parent- and self-reports of adaptive, behavioral, and emotional functioning were obtained. The impact of reduced verbal communication and overreliance on parent-reports are compared to self-report and clinical assessment data. Neurocognitive late effects (executive functioning, processing speed, verbal fluency) were prominent in 2023. Although two extended episodes of atypical behavior emerged in the past year, parent- and self-reports did not indicate any elevated concerns for emotional dysregulation. However, social desirability bias, tendency to underreport emotional symptoms, and an internal negative self-view were significant on self-reports. Although some changes in functioning could be explained by late effects of treatment (Schreiber et al., 2017), others may be better accounted for by social and cultural factors that impact the conceptualization and acceptance of emotional symptoms (Kim et al., 2013). Acknowledging and disclosing emotional difficulties (Liw et al., 2022), as well as seeking mental health care (Abe-Kim et al., 2007), is culturally mediated and can be both protective and/or limiting.

Learning From Atypical Behavior: Temporary Interest Aware Recommendation Based on Reinforcement Learning

Traditional robust recommendation methods view atypical user-item interactions as noise and aim to reduce their impact with some kind of noise filtering technique, which often suffers from two challenges. First, in real world, atypical interactions may signal users' temporary interest different from their general preference. Therefore, simply filtering out the atypical interactions as noise may be inappropriate and degrade the personalization of recommendations. Second, it is hard to acquire the temporary interest since there are no explicit supervision signals to indicate whether an interaction is atypical or not. To address this challenges, we propose a novel model called Temporary Interest Aware Recommendation (TIARec), which can distinguish atypical interactions from normal ones without supervision and capture the temporary interest as well as the general preference of users. Particularly, we propose a reinforcement learning framework containing a recommender agent and an auxiliary classifier agent, which are jointly trained with the objective of maximizing the cumulative return of the recommendations made by the recommender agent. During the joint training process, the classifier agent can judge whether the interaction with an item recommended by the recommender agent is atypical, and the knowledge about learning temporary interest from atypical interactions can be transferred to the recommender agent, which makes the recommender agent able to alone make recommendations that balance the general preference and temporary interest of users. At last, the experiments conducted on real world datasets verify the effectiveness of TIARec.

Preliminary study of all-solid-state batteries: Evaluation of blast formation during the thermal runaway

All-solid-state batteries have been developed to increase energy density by replacing the lithiated graphite negative electrode by a lithium metal foil and to increase safety by removing the organic compounds. However, the safety issues of these batteries have received little attention up to now. The behavior of a reassembled all-solid-state battery under thermal stress was recorded by X-ray radiography and a high-speed camera. The thermal runaway (TR) lasted about 5ms, thus extremely fast reaction kinetics. In comparison, the TR of a lithium-ion battery is about 500ms. Furthermore, a 188-mbar aerial overpressure was measured using a piezoelectric sensor. Although this cell is not an explosive, 2.7g TNT equivalent was calculated for it. This atypical behavior could have an impact on the casing or the battery pack. Therefore, it must be studied in greater detail.